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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2014; 20(28): 9600-9610
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9600
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9600
Gene-diet interactions in gastric cancer risk: A systematic review
Jeongseon Kim, Young Ae Cho, Wook Jin Choi, Seung Hwa Jeong, Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang-si 410-769, South Korea
Author contributions: Kim J and Cho YA designed research paper; Kim J, Cho YA, Choi WJ and Jeong SH performed and analyzed data; Kim J, Cho YA and Choi WJ wrote the paper; Kim J and Cho YA revised the paper.
Supported by A grant from the National Cancer Center, South Korea, No. 1110300 and No. 1410260
Correspondence to: Jeongseon Kim, PhD, Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si 410-769, South Korea. jskim@ncc.re.kr
Telephone: +82-31-9202570 Fax: +82-31-9202579
Received: October 28, 2013
Revised: February 17, 2014
Accepted: May 23, 2014
Published online: July 28, 2014
Revised: February 17, 2014
Accepted: May 23, 2014
Published online: July 28, 2014
Core Tip
Core tip: Gene-diet interactions related to gastric carcinogenesis may provide a unique environment for cancer growth or suppression in each individual. Gene-diet interactions may explain the large variation in gastric cancer incidence in different populations and the inconsistent findings of previous gene or diet studies. Therefore, this review provides an overview of the published epidemiological studies that have investigated the interactions between gene variants and dietary factors associated with gastric cancer risk.