Original Article
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World J Gastroenterol. Jul 28, 2014; 20(28): 9497-9505
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9497
Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence
Jie Tao, Xin-Sen Xu, Yan-Zhou Song, Kai Qu, Qi-Fei Wu, Rui-Tao Wang, Fan-Di Meng, Ji-Chao Wei, Shun-Bin Dong, Yue-Lang Zhang, Min-Hui Tai, Ya-Feng Dong, Lin Wang, Chang Liu
Jie Tao, Xin-Sen Xu, Kai Qu, Rui-Tao Wang, Fan-Di Meng, Ji-Chao Wei, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yan-Zhou Song, Department of General Surgery, Lianyungang First People’s Hospital, Lianyungang 222002, Jiangsu Province, China
Qi-Fei Wu, Department of Thoracic Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yue-Lang Zhang, Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Min-Hui Tai, Ya-Feng Dong, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, KA 66160, United States
Author contributions: Tao J and Xu XS contributed equally to this work; Tao J, Xu XS and Song YZ performed the majority of experiments such as transfection, MTT assay, and invasion assay; Qu K and Wu QF performed the senescence experiment; Wang RT participated in the data analysis; Meng FD and Wei JC constructed the recombinant adenovirus; Dong SB performed cell culture and shRNA selection; Zhang YL and Tai MH performed data analysis; Dong YF and Wang L were involved in editing the manuscript; Liu C designed the study.
Supported by Science Foundation of the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 2010YK1
Correspondence to: Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-85323900 Fax: +86-29-82654746
Received: December 18, 2013
Revised: February 14, 2014
Accepted: April 8, 2014
Published online: July 28, 2014
Processing time: 220 Days and 2.7 Hours
Core Tip

Core tip: Gallbladder cancer is characterized by early metastases, thus it is in urgent need to identify novel therapies to enhance the therapeutic effect. We have previously reported that Forkhead box M1 (FoxM1) expression was closely correlated with gallbladder carcinoma differentiation, Nevin stage and metastasis, indicating the potential roles of FoxM1 in gallbladder carcinoma. In this study, by regulating the expression of FoxM1 with small interfering RNAs, we demonstrated the impact of FoxM1 on cellular viability in a human gallbladder carcinoma cell line, which was probably via the regulation of cellular senescence, revealing FoxM1 as a potential target for gallbladder carcinoma therapy.