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World J Gastroenterol. Jul 28, 2014; 20(28): 9330-9337
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9330
Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations
Sandra Milić, Davorka Lulić, Davor Štimac
Sandra Milić, Davorka Lulić, Davor Štimac, Division of Gastroenterology, Department of Internal Medicine, University Hospital Rijeka, Rijeka 51000, Croatia
Author contributions: Milić S, Lulić D and Štimac D performed data acquisition and wrote the manuscript; Milić S revised the manuscript; Štimac D approved the final manuscript version.
Correspondence to: Sandra Milić, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, University Hospital Rijeka, Krešimirova 42, Rijeka 51000, Croatia. smilic05@gmail.com
Telephone: +385-51-658122 Fax: +385-51-658826
Received: October 29, 2013
Revised: January 26, 2014
Accepted: March 19, 2014
Published online: July 28, 2014
Processing time: 270 Days and 8.3 Hours
Core Tip

Core tip: This article reviews biochemical, metabolic and clinical relationships between non-alcoholic fatty liver disease and obesity. Visceral adipose tissue influences hepatic steatosis to a greater extent than the body mass index, despite evidence that liver fat may develop independent of skeletal muscle and adipose tissue insulin resistance. Obese individuals with non-alcoholic fatty liver disease usually present with symptoms of metabolic syndrome or its components.