Randomized Clinical Trial
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World J Gastroenterol. Jul 21, 2014; 20(27): 9185-9190
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9185
Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease
Brendan M Boyle, Michael D Kappelman, Richard B Colletti, Robert N Baldassano, David E Milov, Wallace V Crandall
Brendan M Boyle, Wallace V Crandall, Nationwide Children’s Hospital, Columbus, OH 43205, United States
Michael D Kappelman, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Richard B Colletti, University of Vermont, Burlington, VT 05405, United States
Robert N Baldassano, Children’s Hospital of Philadelphia, Philadelphia, PA 19146, United States
David E Milov, Nemours Children’s Clinic, Orlando, FL 32806, United States
Author contributions: Boyle BM, Crandall WV and Kappelman MD wrote the paper; Colletti RB, Baldassano RN, and Milov DE provided the manuscript review and designed the development of the PIBDNet cohort registry.
Correspondence to: Brendan M Boyle, MD, MPH, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, United States. brendan.boyle@nationwidechildrens.org
Telephone: +1-614-7223473 Fax: +1-614-7223454
Received: November 7, 2013
Revised: February 28, 2014
Accepted: April 15, 2014
Published online: July 21, 2014
Core Tip

Core tip: This manuscript describes the real world effectiveness of thiopurines in maintaining remission for pediatric Crohn’s disease. The outcomes differ in comparison to the initially published randomized controlled trial for pediatric Crohn’s but are similar to more recently published studies evaluating the effectiveness of thiopurines. The study evaluates data from a pediatric inflammatory bowel disease registry and is representative of real world clinical care. Varitation in practitioner approach to thiopurine dosage and metabolite measurement was found. Implementation of a more standardized approach to use of thiopurines could impact clinical outcomes.