Prospective Study
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World J Gastroenterol. Jul 14, 2014; 20(26): 8691-8699
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8691
Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy
Vladimir D Dugalic, Djordje M Knezevic, Vladan N Obradovic, Miroslava G Gojnic-Dugalic, Slavko V Matic, Aleksandra R Pavlovic-Markovic, Predrag D Dugalic, Srbislav M Knezevic
Vladimir D Dugalic, Djordje M Knezevic, Slavko V Matic, Srbislav M Knezevic, Department of Hepatobiliary and Pancreatic Surgery, First Surgical University Hospital, Clinical Center of Serbia, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Vladan N Obradovic, St. Joseph’s Hospital Health Center, Syracuse, NY 13413, United States
Miroslava G Gojnic-Dugalic, Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Aleksandra R Pavlovic-Markovic, Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Predrag D Dugalic, Clinic for Gastroenterology and Hepatology, University Hospital Zemun, 11000 Belgrade, Serbia
Author contributions: Dugalic VD designed the study, performed surgery, collected and analyzed data and wrote the paper; Knezevic DM, Matic SV and Knezevic SM performed surgery, analyzed and collected data; Pavlovic-Markovic AR and Dugalic PD performed diagnostic procedures; Obradovic VN analyzed data and contributed to manuscript preparation; Gojnic-Dugalic MG analyzed data.
Correspondence to: Vladimir D Dugalić, MD, Department of Hepatobiliary and Pancreatic Surgery, First Surgical University Hospital, Clinical Center of Serbia, 6 Koste Todorovića St., 11000 Belgrade, Serbia. vanjadug@yahoo.com
Telephone: +381-66-8300760
Received: January 17, 2014
Revised: March 7, 2014
Accepted: April 15, 2014
Published online: July 14, 2014
Processing time: 177 Days and 21.9 Hours
Core Tip

Core tip: The aim of the study is to determine the possibility of early prediction of the occurrence of clinically relevant pancreatic fistula (CRPF) during the postoperative period after cephalic duodenopancreatectomy for periampullary carcinoma by measuring drain fluid amylase (DFA) values during the first 3 postoperative days. Three-hundred and eighty-two surgically treated patients with resectable periampullary tumors were prospectively analyzed between 2005 and 2012. The total incidence of pancreatic fistula was 37.7%. The median DFA values were significantly higher in patients who developed CRPF. We concluded DFA could represent a reliable predictive parameter for CRPF development.