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World J Gastroenterol. Jul 14, 2014; 20(26): 8558-8571
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8558
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8558
Changes in circulating Foxp3+ regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure
Xue-Song Liang, Cheng-Zhong Li, Yin Zhou, Wei Yin, Ya-Yun Liu, Wen-Han Fan, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Yin Zhou, Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
Author contributions: Liang XS conceived the study, participated in the design of the study, performed the statistical analysis and drafted the manuscript; Li CZ participated in the design of the study and enrolled the subjects; Zhou Y performed most of the experiments; Yin W collected all of the human material; Liu YY and Fan WH were responsible for patient follow up; all authors read and approved the final manuscript.
Supported by Grants from Shanghai Natural Science Fund, No. 09ZR1400500; National Natural Science Foundation of China No. 30972600; and Shanghai Health Bureau Fund, No. 2012092
Correspondence to: Xue-Song Liang, Associate Professor, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. liangxuesong2000@163.com
Telephone: +86-21-31161902 Fax: +86-21-31161910
Received: October 15, 2013
Revised: December 31, 2013
Accepted: April 8, 2014
Published online: July 14, 2014
Processing time: 272 Days and 15.8 Hours
Revised: December 31, 2013
Accepted: April 8, 2014
Published online: July 14, 2014
Processing time: 272 Days and 15.8 Hours
Core Tip
Core tip: In this study, we longitudinally investigated Foxp3+Treg cells and IL-17+Th cells by measuring gene levels, protein levels and T-cell phenotypes during HBV-related acute-on-chronic liver failure (ACHBLF) progression. From the onset of ACHBLF, there were changes in Foxp3+Treg and Th17 cell frequencies. An increased Treg/Th17 ratio was associated with the survival of ACHBLF patients.