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World J Gastroenterol. Jul 14, 2014; 20(26): 8341-8350
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8341
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8341
Modern approach to the clinical management of non-alcoholic fatty liver disease
Maria Del Ben, Licia Polimeni, Francesco Baratta, Daniele Pastori, Lorenzo Loffredo, Department of Internal Medicine and Medical Specialities, 00161 Rome, Italy
Francesco Angelico, Department of Public Health and Infectious Diseases, Sapienza University, 00161 Rome, Italy
Author contributions: Del Ben M and Polimeni L contributed equally to this work; Del Ben M, Polimeni L and Baratta F analyzed the literature data; Pastori D and Loffredo L reviewed and edited the manuscript; Polimeni L and Angelico F designed the study and wrote the manuscript; all authors read and approved the manuscript.
Correspondence to: Francesco Angelico, MD, Professor of Internal Medicine, Department of Public Health and Infectious Diseases, Sapienza University, 155 viale del Policlinico, 00161 Rome, Italy. francesco.angelico@uniroma1.it
Telephone: +39-06-49972249 Fax: +39-06-49972249
Received: October 2, 2013
Revised: November 5, 2013
Accepted: March 7, 2014
Published online: July 14, 2014
Processing time: 285 Days and 13.4 Hours
Revised: November 5, 2013
Accepted: March 7, 2014
Published online: July 14, 2014
Processing time: 285 Days and 13.4 Hours
Core Tip
Core tip: Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide. Several therapeutic interventions have been proposed, which include moderate weight loss, insulin sensitizer agents, lipid lowering drugs, antioxidants such as vitamin E and treatment of vitamin D3 deficiency. However, therapeutic approaches have been largely empirical and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes so far. Treatment of coexisting metabolic conditions should be regarded as of paramount importance in the management of these patients.