Kwon JE, Koh SJ, Chun J, Kim JW, Kim BG, Lee KL, Im JP, Kim JS, Jung HC. Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis. World J Gastroenterol 2014; 20(25): 8187-8194 [PMID: 25057226 DOI: 10.3748/wjg.v20.i25.8187]
Corresponding Author of This Article
Byeong Gwan Kim, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, Seoul National University Boramae Hospital, 5 Gil 20, Boramae-Road, Dongjak-Gu, Seoul 156-707, South Korea. caskim@brm.co.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Gastroenterol. Jul 7, 2014; 20(25): 8187-8194 Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8187
Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis
Ji Eun Kwon, Seong-Joon Koh, Jaeyoung Chun, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea
Seong-Joon Koh, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul 156-707, South Korea
Author contributions: Kwon JE and Koh SJ contributed equally to this article; Kwon JE, Koh SJ and Kim BG designed the research; Kwon JE, Chun J and Im JP collected sample and interpreted data; Koh SJ, Kim JW, Lee KL, Kim JS and Jung HC contributed statistical analysis and interpretation of data; Kwon JE, Koh SJ and Kim BG wrote the paper.
Correspondence to: Byeong Gwan Kim, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, Seoul National University Boramae Hospital, 5 Gil 20, Boramae-Road, Dongjak-Gu, Seoul 156-707, South Korea. caskim@brm.co.kr
Telephone: +82-2-8702234 Fax: +82-2-8703863
Received: January 20, 2014 Revised: March 18, 2014 Accepted: April 15, 2014 Published online: July 7, 2014 Processing time: 163 Days and 20.9 Hours
Core Tip
Core tip: Bacterial overgrowth/proliferation in an intraluminal environment with a high pH is a well-recognized mechanism for peritonitis development, especially in liver cirrhosis patients. Several studies have investigated whether this mechanism causes peritoneal dialysis (PD)-related peritonitis, although conflicting results have been obtained for the association between acid suppressive therapy and PD-related peritonitis. In addition, no study was conducted to evaluate the association between prokinetics and PD-related peritonitis. Therefore, we sought to assess the effect of gastric acid suppressants and prokinetics on PD-related peritonitis. In the present study, H2B use, but not proton pump inhibitor use, was identified as an independent risk factor for PD-related peritonitis development.
