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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2014; 20(25): 8139-8150
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8139
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8139
Screening of lymph nodes metastasis associated lncRNAs in colorectal cancer patients
Jun Han, Long-Fei Rong, Xiao-Gang Dong, Jie Wang, Bao-Lin Wang, Hao Wen, Zhen-Yu He, Department of General Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China
Chuan-Bin Shi, Department of Pathology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China
Author contributions: Han J, Rong LF and He ZY designed the research; Shi CB, Dong XG, Wang J, Wang BL and Wen H performed the research and analyzed the data; Han J and Rong LF wrote the paper; Han J and Rong LF contributed equally to this work.
Supported by Natural Science Foundation Project of Jiangsu Province, No. BK2012872; and the Science and Technology Projects, Health Department of Jiangsu Province, No. H201207
Correspondence to: Zhen-Yu He, PhD, Department of General Surgery, Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China. hezhenyu1967@163.com
Telephone: +86-25-58509900 Fax: +86-25-58509900
Received: November 15, 2013
Revised: February 15, 2014
Accepted: May 12, 2014
Published online: July 7, 2014
Processing time: 229 Days and 17.2 Hours
Revised: February 15, 2014
Accepted: May 12, 2014
Published online: July 7, 2014
Processing time: 229 Days and 17.2 Hours
Core Tip
Core tip: Long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in a variety of human cancers. However, no data are available regarding their functions in the lymph nodes metastasis of colorectal cancer (CRC). Our study is the first study to focus on lymph nodes metastasis associated lncRNAs in CRC by microarray. Obvious changes of lncRNAs expression profiles were observed in metastatic lymph node, normal lymph node, and tumor tissues of CRC. These changes of lncRNAs may serve as new diagnostic biomarkers and therapeutic targets for lymph node metastasis of CRC.