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World J Gastroenterol. Jul 7, 2014; 20(25): 8119-8129
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8119
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8119
Effect of a high-fat diet in development of colonic adenoma in an animal model
Qing-Chao Zhu, Ren-Yuan Gao, Wen Wu, Bo-Min Guo, Jia-Yuan Peng, Huan-Long Qin, Department of Surgery, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Author contributions: Zhu QC, Gao RY and Wu W conducted the experiments; Guo BM and Peng JY analyzed the data; Zhu QC wrote the manuscript and Qin HL revised the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81230057
Correspondence to: Huan-Long Qin, MD, PhD, Department of Surgery, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. huanlongqin@yahoo.com
Telephone: +86-21-64361349 Fax: +86-21-64361349
Received: December 7, 2013
Revised: March 10, 2014
Accepted: April 5, 2014
Published online: July 7, 2014
Revised: March 10, 2014
Accepted: April 5, 2014
Published online: July 7, 2014
Core Tip
Core tip: This study was undertaken to explore the effect of a high-fat diet on the incidence of colonic adenoma induced by intraperitoneal injection of 1,2-dimethylhydrazine in Wistar rats. We demonstrated that a high-fat diet (HFD) increased the proliferative activity of colonic epithelial cells, and we conclude that HFD-mediated tumor growth could be associated with inflammation and increased cell cycle progression. This study might be conducive to understanding the nature of the relationship between high fat intake and the increased risk of colorectal carcinoma.