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World J Gastroenterol. Jun 21, 2014; 20(23): 7497-7504
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7497
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7497
Association between orofacial granulomatosis and Crohn’s disease in children: Systematic review
Marzia Lazzerini, Matteo Bramuzzo, Alessandro Ventura, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Matteo Bramuzzo, Alessandro Ventura, University of Trieste, 34137 Trieste, Italy
Author contributions: Lazzerini M, Bramuzzo M and Ventura A contributed equally to the work; Lazzerini M conceptualized and designed the review together with Ventura A; Lazzerini M and Bramuzzo M carried out the analysis; Lazzerini M drafted the initial manuscript; all authors reviewed and approved the final manuscript as submitted.
Correspondence to: Marzia Lazzerini, PhD, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, Italy. marzia.lazzerini@burlo.trieste.it
Telephone: +39-40-3785555 Fax: +39-40-3785260
Received: September 27, 2013
Revised: January 17, 2014
Accepted: April 1, 2014
Published online: June 21, 2014
Revised: January 17, 2014
Accepted: April 1, 2014
Published online: June 21, 2014
Core Tip
Core tip: This systematic review of children with orofacial granulomatosis (OFG) resulted in the following main findings: (1) 40.4% of children with OFG were affected by Crohn’s disease during their life; (2) 12.1% of children with OFG had perianal disease; (3) 6.4% had a positive family history for Crohn’s disease; (4) both OFG and Crohn’s disease were more prevalent in boys; and (5) both diseases had a long-term course, and treatment resembled the treatment used for Crohn’s disease. Taken together, these findings suggest that OFG may be a subtype of Crohn’s disease.