Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2014; 20(23): 7434-7441
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7434
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7434
Hepatitis B transmission by cell and tissue allografts: How safe is safe enough?
Pilar Solves, Vicente Mirabet, Manuel Alvarez, Blood Bank, Hospital Universitari I Politècnic La Fe, Bulevar Sur, 46026 Valencia, Spain
Author contributions: Mirabet V and Alvarez M exhaustively reviewed the literature and wrote the paper; Solves P wrote the paper and critically reviewed it.
Correspondence to: Pilar Solves, MD, Blood Bank, Hospital Universitari I Politècnic La Fe, Bulevar Sur, 46026 Valencia, Spain. solves_pil@gva.es
Telephone: +34-96-3868142 Fax: +34-96-3502469
Received: October 28, 2013
Revised: January 4, 2014
Accepted: February 17, 2014
Published online: June 21, 2014
Revised: January 4, 2014
Accepted: February 17, 2014
Published online: June 21, 2014
Core Tip
Core tip: Human tissue transplantation is a current practice that still represents a risk for hepatitis B virus transmission (HBV). HBV detection is included in the routine screening tests for cell and tissue donors. The implementation of methods involving nucleic acid amplification has increased the sensitivity and specificity of the screening tests. The aim of this review is to update the knowledge of the risk of hepatitis transmission through tissue transplantation and critically analyze current screening tests.