Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2014; 20(22): 7011-7018
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7011
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7011
Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital “Dr. José E. Gonzalez” and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México
Fernando Javier Lavalle-González, Jesús Zacarías Villarreal-Pérez, Endocrinology Service and Department of Internal Medicine, University Hospital “Dr. José E. González” and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México
Linda Elsa Muñoz-Espinosa, Liver Unit, University Hospital “Dr. José E. González” and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México
Author contributions: García-Compeán D designed and coordinated the research and wrote the manuscript; Jáquez-Quintana JO and González-González JA evaluated patients at inclusion and follow-up; Lavalle-González FJ and Villarreal-Pérez JZ participated in laboratory testings and revision of the manuscript; Muñoz-Espinosa LE and Maldonado-Garza HJ reviewed the manuscript.
Supported by Gastroenterology and Endocrinology Services of the University Hospital, Universidad Autónoma de Nuevo León, Monterrey, México
Correspondence to: Diego García-Compeán, MD, Gastroenterology Service and Department of Internal Medicine, University Hospital “Dr. José E. Gonzalez” and Medical School, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, Monterrey 64320, México. digarciacompean@prodigy.net.mx
Telephone: +52-81-83487315 Fax:+52-81-89891381
Received: November 10, 2013
Revised: February 5, 2014
Accepted: March 19, 2014
Published online: June 14, 2014
Processing time: 218 Days and 12.8 Hours
Revised: February 5, 2014
Accepted: March 19, 2014
Published online: June 14, 2014
Processing time: 218 Days and 12.8 Hours
Core Tip
Core tip: In this controlled prospective long term study we demonstrated that subclinical forms of abnormal glucose tolerance (IGT) or diabetes mellitus (DM) may influence survival of non-diabetic cirrhotic patients. Previously it had been demonstrated that clinically overt DM is associated with low survival of cirrhotic patients. This issue is important since a high proportion of cirrhotic patients (about 70%) without history of DM and with normal fasting plasma glucose have subclinical abnormal glucose tolerance. The use of oral glucose tolerance test for early recognition and treatment of DM may improve prognosis of these patients.