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World J Gastroenterol. Jun 14, 2014; 20(22): 6897-6905
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6897
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6897
Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats
Zi-Bin Tian, Run-Jun Deng, Liang-Zhou Wei, Xin-Juan Kong, Xue-Li Ding, Xue Jing, Cui-Ping Zhang, Department of Gastroenterology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
Gui-Rong Sun, Clinical Laboratory, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
Yin-Lin Ge, Department of Biochemistry and Molecular Biology, Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Tian ZB, Deng RJ, Sun GR, Wei LZ, and Kong XJ were involved in study concept and design; Deng RJ, Ding XL and Jing X performed the study; Zhang CP and Ge YL analyzed the experimental data; Deng RJ and Tian ZB wrote the manuscript.
Supported by Grants from National Natural Science Foundation of China, No. 81070305; and the Natural Science Foundation of Shandong Province, No. zr2010hm066
Correspondence to: Zi-Bin Tian, MD, Department of Gastroenterology, Affiliated Hospital of Medical College of Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. tianzb@qdumh.qd.sd.cn
Telephone: +86-532-82911302 Fax: +86-532-82911302
Received: December 11, 2013
Revised: January 5, 2014
Accepted: April 1, 2014
Published online: June 14, 2014
Processing time: 186 Days and 18.6 Hours
Revised: January 5, 2014
Accepted: April 1, 2014
Published online: June 14, 2014
Processing time: 186 Days and 18.6 Hours
Core Tip
Core tip: We report that nesfatin-1 level in the stomach and duodenum is positively correlated with body mass. To our knowledge, this is the first time to detect the nesfatin-1 level in the duodenum, small intestine and colon with traditional obese and lean subjects induced by nuclei lesions. Additionally, the data of gastric nefatin-1 expression are an objective supplement to the previous report. Notably, we also show a positive relationship between gastric emptying and body mass. Further, it is possible that the expression level of gastrointestinal nesfatin-1 may be used to diagnose the gastric mobility disorder and metabolism disturbance.