Case Control Study
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World J Gastroenterol. Jun 7, 2014; 20(21): 6573-6579
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6573
Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis
Đorđe Ćulafić, Miloš Štulić, Radmila Obrenović, Danijela Miletić, Dragana Mijač, Milica Stojković, Marija Jovanović, Milica Ćulafić
Đorđe Ćulafić, Danijela Miletić, Dragana Mijač, Milica Stojković, MilošŠtulić, Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia, and School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Radmila Obrenović, Institute of Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia
Marija Jovanović, Milica Ćulafić, Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia
Author contributions: Ćulafić Đ and Štulić M contributed equally to this work; Ćulafić Đ and Štulić M designed the research; Ćulafić Đ, Štulić M, Miletić D, Mijač D and Stojković M performed the research; Obrenović R performed the biochemical analysis; Jovanović M and Ćulafić M analyzed the data; Ćulafić Đ, Štulić M and Ćulafić M wrote the paper.
Supported by Ministry of Education, Science and Technological Development, Belgrade, Republic of Serbia, Project No. 175036
Correspondence to: Milica Ćulafić, MSc, Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450 Street, 11000 Belgrade, Serbia. milica.culafic@gmail.com
Telephone: +381-11-3951375 Fax: +381-11-3951373
Received: January 1, 2014
Revised: February 18, 2014
Accepted: March 19, 2014
Published online: June 7, 2014
Processing time: 156 Days and 14.9 Hours
Core Tip

Core tip: Early diagnosis of renal dysfunction is important to prevent serious complications. We conducted a study of 63 patients with liver cirrhosis and 30 healthy controls. Serum cystatin C (CysC) was measured and renal Doppler ultrasonography was performed. More patients with decreased glomerular filtration rate (GFR) were identified based on CysC GFR than on creatinine GFR. Higher renal resistive index in advanced disease by Child-Pugh and model of end stage liver disease was noticed. Renal resistive index (RRI) correlated with CysC and negatively correlated with glomerular filtration rate from serum cystatin C. Cystatin C may be a more reliable marker for liver insufficiency assessment. CysC and RRI represent sensitive indicators of renal dysfunction in liver cirrhosis.