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World J Gastroenterol. Jun 7, 2014; 20(21): 6541-6546
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6541
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6541
Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis
Naoki Hashimoto, Department of Surgery, Kinki University, Osaka 589-8511, Japan
Author contributions: Hashimoto N solely contributed to this paper.
Correspondence to: Naoki Hashimoto, MD, PhD, Department of Surgery, Kinki University, 377-2 Ohonohigashi, Osakasayama, Osaka 589-8511, Japan. gojigen000@gmail.com
Telephone: +81-723-660221 Fax: +81-723-683382
Received: October 11, 2013
Revised: February 28, 2014
Accepted: March 12, 2014
Published online: June 7, 2014
Revised: February 28, 2014
Accepted: March 12, 2014
Published online: June 7, 2014
Core Tip
Core tip: It is known that reflux of duodenal contents (bile acids) can induce mucosal injury, stimulate cell proliferation, and promote tumorigenesis. We examined the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 in rat esophageal lesions induced by reflux of duodenal contents. All animals underwent an esophagoduodenal anastomosis with total gastrectomy to elicit chronic esophagitis. We demonstrated that reflux of duodenal contents induces COX-2 and increases prostaglandin synthesis in dysplastic and cancer tissues. This result suggests a possible mechanism by which bile acids promote esophageal cancer.