Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass

doi:10.3748/wjg.v20.i21.6534

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2014; 20(21): 6534-6540
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6534

Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass

Andrés Marambio, Guillermo Watkins, Fabiola Castro, Andrea Riffo, Roberta Zúñiga, Jaime Jans, María E Villanueva, Guillermo Díaz

Andrés Marambio, Guillermo Watkins, Andrea Riffo, Jaime Jans, Department of Surgery, University of Chile Clinical Hospital, Santiago 8380456, Chile

Fabiola Castro, Department of Gastroenterology, Chilean Air Force Clinical Hospital, Santiago 7560171, Chile

Roberta Zúñiga, Guillermo Díaz, Department of Pharmacological and Toxicological Chemistry, University of Chile Chemistry and Pharmacy Faculty, Santiago 8380492, Chile

María E Villanueva, Pathology Service, University of Chile Clinical Hospital, Santiago 8380456, Chile

Author contributions: Marambio A participated in the conception and design of the study, acquisition, analysis and interpretation of data, and drafting the article and finally approving it; Watkins G participated in the conception and design of the study, revising the article critically and finally approving it; Castro F participated in the conception and design of the study, revising the article critically and finally approving it; Riffo A participated in the acquisition of data, revising the article critically and finally approving it; Zúñiga R participated in the acquisition, analysis and interpretation of data and drafting the article and finally approving it; Jans J participated in the acquisition of data, drafting the article and finally approving it; Villanueva ME participated in the analysis and interpretation of data, revising the article critically and finally approving it; and Díaz G participated in the conception and design of the study, analysis and interpretation of data, revising the article critically and finally approving it.

Supported by “2009 Clinical and Basic Clinical Research Contest” of the Bureau for Clinical Research Support from the University of Chile Clinical Hospital

Correspondence to: Dr. Andrés Marambio, Department of Surgery, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago 8380456, Chile. amarambio@med.uchile.cl

Telephone: +56-2-29788329 Fax: +56-2-27370844

Received: September 15, 2013
Revised: December 5, 2013
Accepted: January 8, 2014
Published online: June 7, 2014

Core Tip

Core tip: Anaemia after Roux-en-Y gastric bypass surgery is one of the most common nutritional deficiencies. Different nutritional supplementation strategies have been developed to prevent this complication, but a subset of patients still develop it. This study brings readers the first report on the molecular changes that occur in the physiology of iron absorption in these patients.