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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2014; 20(21): 6515-6522
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6515
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6515
miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2
Yong-Bin Zheng, Hai-Ping Luo, Qiang Shi, Zhi-Nan Hao, Yu Ding, Qiu-Shuang Wang, Sheng-Bo Li, Gao-Chun Xiao, Shi-Lun Tong, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Zheng YB designed the research; Li HP, Shi Q and Hao ZN performed the research; Ding Y, Wang QS and Li SB collected the clinical data; Xiao GC and Tong SL analyzed the data; and Zheng YB and Luo HP wrote the paper.
Correspondence to: Yong-Bin Zheng, MD, PhD, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi Dong Road, Wuchang District, Wuhan 430060, Hubei Province, China. yongbinzheng11@163.com
Telephone: +86-27-87345657 Fax: +86-27-87345879
Received: January 13, 2014
Revised: March 4, 2014
Accepted: April 30, 2014
Published online: June 7, 2014
Revised: March 4, 2014
Accepted: April 30, 2014
Published online: June 7, 2014
Core Tip
Core tip: In this study, we reported the clinical significance and biological effects of miR-132 in colorectal cancer (CRC). We found that miR-132 was significantly down-regulated in tumor cell lines and CRC tissues with distant metastases. Down-regulation of miR-132 was associated with aggressive tumor phenotypes and adverse prognosis in CRC patients. Moreover, we showed that ectopic expression of miR-132 significantly inhibited cell invasion and the epithelial-mesenchymal transition (EMT), whereas knockdown of miR-132 promoted cell invasion and EMT in CRC cells. Further investigation revealed ZEB2, an EMT regulator, was a downstream target of miR-132.