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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2014; 20(21): 6495-6503
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6495
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6495
Involvement of heat shock proteins in gluten-sensitive enteropathy
Erna Sziksz, Tivadar Tulassay, Ádám Vannay, MTA-SE, Pediatrics and Nephrology Research Group, H-1083 Budapest, Hungary
Erna Sziksz, Domonkos Pap, Gábor Veres, Tivadar Tulassay, Ádám Vannay, First Department of Pediatrics, Semmelweis University, H-1083 Budapest, Hungary
Andrea Fekete, MTA-SE, “Lendulet” Diabetes Research Group, H-1083 Budapest, Hungary
Author contributions: Sziksz E and Vannay Á designed the concept for this review and wrote the manuscript; Pap D contributed to the literature search; Veres G, Fekete A and Tulassay T contributed to the final revision of the article; all authors approved the final version of the manuscript.
Supported by OTKA-84087/2010, -K81117, -K105530, -PD83431, -PD105361, “Lendulet” Research Grant LP2011-008, 2011 and KMR_12-1-2012-0074; Vannay Á and Veres G are holders of the János Bolyai Research Grant by János Bolyai Research Scholarship of the Hungarian Academy of Sciences
Correspondence to: Erna Sziksz, PhD, MTA-SE, Pediatrics and Nephrology Research Group, Bokay Janos utca 53-54, H-1083 Budapest, Hungary. sziksz.erna@med.semmelweis-univ.hu
Telephone: +36-1-3343186 Fax: +36-1-3138212
Received: November 21, 2013
Revised: February 12, 2014
Accepted: March 7, 2014
Published online: June 7, 2014
Revised: February 12, 2014
Accepted: March 7, 2014
Published online: June 7, 2014
Core Tip
Core tip: The only current effective therapy for the treatment of coeliac disease (CD) is a gluten-free diet. However, therapies targeting heat shock proteins (HSPs) for the treatment of various autoimmune disorders and cancers have been developed and have shown promising results. As CD is an autoimmune disorder, these new therapies may prove beneficial as an alternative treatment strategy. This review highlights and discusses recent data concerning the involvement of HSPs in the pathophysiology of CD.