Epigenetics: An emerging player in gastric cancer

doi:10.3748/wjg.v20.i21.6433

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 7, 2014; 20(21): 6433-6447
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6433

Epigenetics: An emerging player in gastric cancer

Changwon Kang, Ji-Joon Song, Jaeok Lee, Mi Young Kim

Changwon Kang, Ji-Joon Song, Jaeok Lee, Mi Young Kim, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea

Author contributions: Kang C and Kim MY contributed equally to this work; Kang C, Song JJ and Kim MY designed and wrote the manuscript; and Lee J searched the literature and outlined the manuscript.

Supported by National Research Foundation of Korea, No. 2013056334

Correspondence to: Mi Young Kim, PhD, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, South Korea. miyoungkim@kaist.ac.kr

Telephone: +82-42-3502615 Fax: +82-42-3502610

Received: December 1, 2013
Revised: January 7, 2014
Accepted: February 17, 2014
Published online: June 7, 2014
Processing time: 186 Days and 17.5 Hours

Core Tip

Core tip: The pathogenesis of gastric, or stomach cancer has long been a topic of extensive research, and these research efforts have resulted in tremendous improvements in the diagnosis and treatment of gastric cancer patients. However, research on gastric cancer has been focused on the genetic and environmental determinants of its formation and progression while the role of regulators, another important set of contributors to gastric cancer, has just begun to be elucidated. In this review, we highlight our current understanding of the epigenetic mechanisms by which gastric cancer arises and progresses and discuss future research directions.