Pan ZG, Xiao C, Su DX. No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: Evidence from a meta-analysis. World J Gastroenterol 2014; 20(20): 6345-6352 [PMID: 24876757 DOI: 10.3748/wjg.v20.i20.6345]
Corresponding Author of This Article
Dr. Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, 13 Dancun Road, Nanning 530031, Guangxi Zhuang Autonomous Region, China. 553851548@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
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World J Gastroenterol. May 28, 2014; 20(20): 6345-6352 Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6345
No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: Evidence from a meta-analysis
Zhi-Gang Pan, Chen Xiao, Dong-Xing Su
Zhi-Gang Pan, Chen Xiao, Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China
Author contributions: Su DX and Pan ZG conceived the study and implemented the final draft of the manuscript; Pan ZG and Xiao C performed the statistical analysis and wrote the paper; Pan ZG and Xiao C searched the studies and extracted the data; all authors read and approved the final manuscript.
Correspondence to: Dr. Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, 13 Dancun Road, Nanning 530031, Guangxi Zhuang Autonomous Region, China. 553851548@qq.com
Telephone: +86-771-2246364 Fax: +86-771-2246523
Received: November 23, 2013 Revised: December 15, 2013 Accepted: January 14, 2014 Published online: May 28, 2014 Processing time: 185 Days and 13.5 Hours
Core Tip
Core tip: G-protein beta polypeptide 3 (GNB3) polymorphisms have been identified as an independent risk factor causally associated with functional gastrointestinal disorder and receive extensive interest. However, their association with irritable bowel syndrome (IBS) remains controversial. In the present paper, the authors combined the data from seven case-control studies with 1085 IBS cases and 1695 controls, and found that there were associations between GNB3 C825T polymorphism and IBS risk in the overall population; subgroup analysis did not reveal significant associations either in Asian population or Caucasian population. In regard to the subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type), no associations were found either.
