Role of microRNAs in gastric cancer

doi:10.3748/wjg.v20.i19.5694

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May 21, 2014 (publication date) through May 7, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2014; 20(19): 5694-5699
Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5694

Role of microRNAs in gastric cancer

Hideyuki Ishiguro, Masahiro Kimura, Hiromitsu Takeyama

Hideyuki Ishiguro, Masahiro Kimura, Hiromitsu Takeyama, Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan

Author contributions: Ishiguro H and Kimura M gathered the papers and performed the research; Ishiguro H and Takeyama H analyzed the data and wrote the paper.

Correspondence to: Hideyuki Ishiguro, MD, PhD, Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi Mizuho-cho Mizuho-ku, Nagoya 467-8601, Japan. h-ishi@med.nagoya-cu.ac.jp

Telephone: +81-52-8538226 Fax: +81-52-8423906

Received: October 26, 2013
Revised: December 11, 2013
Accepted: January 19, 2014
Published online: May 21, 2014

Core Tip

Core tip: In this review, we discuss the involvement of miRNAs in gastric cancer (GC) and the mechanisms through which they regulate gene expression and biological functions. Then, we review recent research on the involvement of miRNAs in GC prognosis, their potential use in chemotherapy, and their effects on Helicobacter pylori infections in GC. A greater understanding of the roles of miRNAs in gastric carcinogenesis could provide insights into the mechanisms of tumor development and could help to identify novel therapeutic targets.