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World J Gastroenterol. May 14, 2014; 20(18): 5505-5510
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5505
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5505
Arsenic trioxide induces apoptosis of human gastrointestinal cancer cells
Zhi-Bin Ma, Hong-Yu Xu, Miao Jiang, You-Lin Yang, Lian-Xin Liu, Department of Gastroenterology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Ying-Hua Li, Department of Hematology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Ma ZB and Xu HY contributed equally to this study, and are co-first authors; Ma ZB and Xu HY were responsible for statistical analysis of the data; Jiang M was responsible for the immunohistochemistry analysis; Yang YL was responsible for pre-treatment sample collection and specimen collection; Liu LX was responsible for clinical use; Li YH was the main designer of this study.
Supported by The Heilongjiang Provincial Natural Science Foundation of China, No. D2006-51
Correspondence to: Ying-Hua Li, MD, PhD, Department of Hematology, First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. mazhibin1973117@126.com
Telephone: +86-451-85555119 Fax: +86-451-85555119
Received: October 13, 2013
Revised: February 2, 2014
Accepted: March 6, 2014
Published online: May 14, 2014
Revised: February 2, 2014
Accepted: March 6, 2014
Published online: May 14, 2014
Core Tip
Core tip: In this study, patients with gastrointestinal cancer were treated with arsenic trioxide for the first time. The use of arsenic trioxide in neoadjuvant chemotherapy prior to surgery improved surgical results.