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World J Gastroenterol. May 14, 2014; 20(18): 5420-5426
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5420
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5420
Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment
Kang Li, Zeng Dan, Department of Gastroenterology, People’s Hospital of Tibet Autonomous Region, Lhasa 850000, Tibet Autonomous Region, China
Kang Li, Yu-Qiang Nie, Department of Gastroenterology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong Province, China
Author contributions: Li K designed the study; Li K and Dan Z performed the research; Li K and Nie YQ wrote the manuscript.
Correspondence to: Kang Li, MD, Department of Gastroenterology, People’s Hospital of Tibet Autonomous Region, 18 North Lin Kuo Road, Lhasa 850000, Tibet Autonomous Region, China. likang820@aliyun.com
Telephone: +86-891-6333324 Fax: +86-891-6371511
Received: October 11, 2013
Revised: January 15, 2014
Accepted: February 26, 2014
Published online: May 14, 2014
Revised: January 15, 2014
Accepted: February 26, 2014
Published online: May 14, 2014
Core Tip
Core tip: Gastric cancer stem cells (GCSCs) play an important role in the occurrence and development of gastric cancer. They are the basis for tolerance to chemotherapy, as well as the rapid growth and metastasis of tumors. GCSC markers are closely associated with the degree of malignancy of gastric cancer, therefore, marker-targeted therapy is one of the potential directions for the treatment of gastric cancer.