Topic Highlight
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World J Gastroenterol. May 14, 2014; 20(18): 5294-5301
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5294
Helicobacter pylori neutrophil-activating protein: From molecular pathogenesis to clinical applications
Hua-Wen Fu
Hua-Wen Fu, Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
Author contributions: Fu HW contributed to this work.
Supported by National Science Council of Taiwan, No. NSC101-2311-B-007-007
Correspondence to: Hua-Wen Fu, Associate Professor, Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, 101, Sec. 2, Kuang-Fu Rd., Hsinchu 30013, Taiwan. hwfu@life.nthu.edu.tw
Telephone: +886-3-5742485 Fax: +886-3-5715934
Received: September 30, 2013
Revised: December 2, 2013
Accepted: January 6, 2014
Published online: May 14, 2014
Core Tip

Core tip:Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) acts as a virulence factor to play a pathogenic role in H. pylori infection. However, the unique immune properties and biological function of HP-NAP make it a potential candidate for clinical applications, including vaccine development, clinical diagnosis, and drug development.