Copyright
©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 14, 2014; 20(18): 5244-5251
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5244
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5244
Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy
Kaname Uno, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University, Miyagi 981-8574, Japan
Katsuaki Kato, Center of Cancer Screening, Miyagi Cancer Society, Miyagi 980-0011, Japan
Author contributions: Uno K and Kato K contributed equally to this article; Uno K and Kato K wrote and drafted this review; Shimosegawa T participated in final approval.
Correspondence to: Katsuaki Kato, MD, PhD, Center of Cancer Screening, Miyagi Cancer Society, 5-7-30, Kamisugi, Aoba-ku, Sendai, Miyagi 980-0011, Japan. kkato@cat-v.ne.jp
Telephone: +81-22-2631525 Fax: +81-22-2631525
Received: September 20, 2013
Revised: December 13, 2013
Accepted: January 6, 2014
Published online: May 14, 2014
Processing time: 238 Days and 7.7 Hours
Revised: December 13, 2013
Accepted: January 6, 2014
Published online: May 14, 2014
Processing time: 238 Days and 7.7 Hours
Core Tip
Core tip: Toll-like receptors (TLRs) play important roles not only in the first line of defense against Helicobacter pylori (H. pylori), but also in gastric carcinogenesis. TLR signaling initiated by pathogen-associated molecular patterns of H. pylori consequently works to establish antigen-specific acquired immune responses. Simultaneously, damage-associated molecular patterns produced by chronic inflammation may contribute to gastric cancer development. A better understanding of TLRs will provide new insights into new diagnostic/predictive biomarkers and therapeutic targets for H. pylori-associated gastric cancer.