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World J Gastroenterol. May 14, 2014; 20(18): 5226-5234
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5226
Metabolic consequences of Helicobacter pylori infection and eradication
György Miklós Buzás
György Miklós Buzás, Department of Gastroenterology, Ferencváros Health Centre, 1095 Budapest, Hungary
Author contributions: Buzás GM contributed solely to conception, design, literature search, data interpretation, conceived and drafted the manuscript.
Correspondence to: György Miklós Buzás, MD, PhD, Chief Gastroenterologist, Department of Gastroenterology, Ferencváros Health Centre, Mester utca 45, 1095 Budapest, Hungary. drbgym@gmail.com
Telephone: +36-1-45454571 Fax: +36-1-4554504
Received: September 7, 2013
Revised: December 16, 2013
Accepted: January 14, 2014
Published online: May 14, 2014
Processing time: 248 Days and 17.5 Hours
Core Tip

Core tip: Although Helicobacter pylori (H. pylori) in considered the main cause of peptic ulcer, gastric cancer and mucosa-associated lymphoid tissue lymphoma, the infection could induce many extragastric manifestations: among them, the metabolic disturbances are less well debated. Growth-as expression of general metabolism-could be delayed especially in low income-high infection prevalence regions and this can be restored by timely eradication of the infection. H. pylori infection may be associated with increased total and low density lipoprotein cholesterol and decrease of high density liporotein, creating an atherogenic lipid profile and promoting atherosclerosis. H. pylori is consistently associated with insulin resistance. In the future, larg-scale studies are needed to clarify if eradication of H. pylori will result in restoration of normal growth, decrease of atherosclerotic disease, type 2 diabetes mellitus and metabolic syndrome.