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World J Gastroenterol. May 7, 2014; 20(17): 5131-5134
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5131
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5131
One case of intrahepatic cholangiocarcinoma amenable to resection after radioembolization
Cecilia Servajean, Marine Gilabert, Jean-Luc Raoul, Department of Medical Oncology, Paoli-Calmettes Institute, 13273 Marseille, France
Gilles Piana, Department of Radiology, Paoli-Calmettes Institute, 13273 Marseille, France
Geneviève Monges, Department of Pathology, Paoli-Calmettes Institute, 13273 Marseille, France
Jean-Robert Delpero, Department of Digestive Surgery, Paoli-Calmettes Institute, 13273 Marseille, France
Isabelle Brenot, Department of Nuclear Medicine, Paoli-Calmettes Institute, 13273 Marseille, France
Author contributions: All authors participated in the diagnosis, management and follow-up of this clinical case and have reviewed, corrected and approved this final version of the manuscript.
Correspondence to: Jean-Luc Raoul, Professor, Department of Medical Oncology, Paoli-Calmettes Institute, 232 Boulevard de Sainte Marguerite, BP 156, 13273 Marseille, France. raouljl@ipc.unicancer.fr
Telephone: +33-4-91223679 Fax: +33-4-91223670
Received: November 15, 2013
Revised: December 25, 2013
Accepted: February 20, 2014
Published online: May 7, 2014
Processing time: 173 Days and 8 Hours
Revised: December 25, 2013
Accepted: February 20, 2014
Published online: May 7, 2014
Processing time: 173 Days and 8 Hours
Core Tip
Core tip: A 57-year-old man with abdominal pain was diagnosed with a large unresectable hepatic tumor. On liver biopsy, this intrahepatic cholangiocarcinoma was observed within the normal liver parenchyma. After 2 systemic chemotherapy regimens, the tumor remained stable. A radioembolization (SIRS-Spheres®) delivering 120 Gy to the tumor, 7 Gy to the normal liver and 4 Gy to the lungs was performed. Three months later, the tumor was less vascularized and had shrunk, and a resection could be performed. On pathological examination, most of the tumor was acellular with fibrosis centered on microspheres, and only a few viable cells were noticed.