Clinical Trials Study
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World J Gastroenterol. May 7, 2014; 20(17): 5092-5097
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5092
Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture
Yoshiyasu Kono, Ryuta Takenaka, Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Seiji Kawano, Yasushi Yamasaki, Koji Takemoto, Takayoshi Miyake, Shigeatsu Fujiki, Kazuhide Yamamoto
Yoshiyasu Kono, Yasushi Yamasaki, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Yoshiyasu Kono, Yasushi Yamasaki, 2nd Department of Internal Medicine, Tsuyama Chuo Hospital, Okayama 708-0841, Japan
Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Internal Medicine, Tsuyama Chuo Hospital, Okayama 708-0841, Japan
Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Seiji Kawano, Department of Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan
Takayoshi Miyake, Department of Pathology, Tsuyama Chuo Hospital, Okayama 708-0841, Japan
Author contributions: Kono Y drafted the article, analyzed and interpreted the data; Takenaka R and Kawahara Y designed the research, revised the article for important intellectual content; Hori K, Kawano S, Yamasaki Y, Takemoto K and Miyake T analyzed and interpreted the data; Okada H, Fujiki S and Yamamoto K finally approved the article.
Correspondence to: Yoshiyasu Kono, MD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. hxnwq178@yahoo.co.jp
Telephone: +81-86-2357219  Fax: +81-86-2255991
Received: November 29, 2013
Revised: February 13, 2014
Accepted: March 4, 2014
Published online: May 7, 2014
Core Tip

Core tip: A novel chromoendoscopy procedure using an acetic acid indigocarmine mixture (AIM) is effective for recognizing the margins of early gastric cancer (EGC). In some cases the color of the EGC area gradually becomes reddish after instillation of the AIM solution. The study shows that the sensitivity of AIM-chromoendoscopy (AIM-CE) in the diagnosis of EGC was significantly higher than that of white light endoscopy, but the specificity and accuracy were not. AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy.