Kovács M, Müller KE, Papp M, Lakatos PL, Csöndes M, Veres G. New serological markers in pediatric patients with inflammatory bowel disease. World J Gastroenterol 2014; 20(17): 4873-4882 [PMID: 24803798 DOI: 10.3748/wjg.v20.i17.4873]
Corresponding Author of This Article
Gábor Veres, MD, PhD, 1st Department of Pediatrics, Semmelweis University, 53 Bókay Street, 1083 Budapest, Hungary. veres.gabor@med.semmelweis-univ.hu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. May 7, 2014; 20(17): 4873-4882 Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.4873
New serological markers in pediatric patients with inflammatory bowel disease
Márta Kovács, Katalin Eszter Müller, Mária Papp, Péter László Lakatos, Mihály Csöndes, Gábor Veres
Márta Kovács, Department of Pediatrics, Petz Aladár County and Teaching Hospital, 9023 Győr, Hungary
Katalin Eszter Müller, Gábor Veres, 1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary
Mária Papp, 2nd Department of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Péter László Lakatos, 1st Department of Medicine, Semmelweis University, 1083 Budapest, Hungary
Mihály Csöndes, Department of Gastroenterology, Petz Aladár County and Teaching Hospital, 9023 Győr, Hungary
Author contributions: Kovács M performed the research and wrote the paper; Müller KE, Papp M, Lakatos PL and Csöndes M made the critical revision; Veres G designed the research, wrote the paper, and made critical revisions.
Supported by The János Bolyai Research and Scholarship of the Hungarian Academy of Sciences, OTKA-K 105530
Correspondence to: Gábor Veres, MD, PhD, 1st Department of Pediatrics, Semmelweis University, 53 Bókay Street, 1083 Budapest, Hungary. veres.gabor@med.semmelweis-univ.hu
Telephone: +36-1-3343743 Fax: +36-1-3036077
Received: November 12, 2013 Revised: January 16, 2014 Accepted: March 6, 2014 Published online: May 7, 2014 Processing time: 175 Days and 11.8 Hours
Core Tip
Core tip: Application of non-invasive diagnostic tests for the diagnosis of inflammatory bowel disease (IBD) and differentiation between ulcerative colitis (UC) and Crohn’s disease (CD) would be useful in the pediatric population. The combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody improved the sensitivity of serological markers in pediatric patients with CD and UC. In addition, serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression. With this knowledge, clinicians will be able to stratify patients accordingly with regards to the risk of disease progression, create a personalized treatment strategy, and attempt to modify disease course, thereby improving long-term prognosis.
