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World J Gastroenterol. May 7, 2014; 20(17): 4857-4872
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.4857
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.4857
Venous thrombosis and prothrombotic factors in inflammatory bowel disease
Fernando Magro, Gastroenterology Department of Centro Hospitalar São João, 4200-319 Porto, Portugal
Fernando Magro, Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Fernando Magro, IBMC, Institute for Molecular and Cell Biology, University of Porto, 4150-180 Porto, Portugal
João-Bruno Soares, Dália Fernandes, Gastroenterology Department of Hospital de Braga, 4710-243 Braga, Portugal
Dália Fernandes, Gastroenterology Department of Centro Hospitalar da Cova da Beira, 6200-251 Covilhã, Portugal
Author contributions: Magro F and Soares JB contributed equally to this work; Magro F and Soares JB contributed to the conception and design, acquisition, analysis and interpretation of data, drafting and revising of the article for important intellectual content and final approval of the version to be published; Fernandes D contributed to the acquisition, analysis and interpretation of data, drafting of the article and final approval of the version to be published.
Correspondence to: Fernando Magro, MD, PhD, Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. fm@med.up.pt
Telephone: +351-22-5513600 Fax: +351-22-5513601
Received: September 29, 2013
Revised: January 12, 2014
Accepted: March 12, 2014
Published online: May 7, 2014
Revised: January 12, 2014
Accepted: March 12, 2014
Published online: May 7, 2014
Core Tip
Core tip: In inflammatory bowel disease (IBD), there is an increased risk of venous thrombosis (VTE) due to inflammatory activity, hospitalisation, surgery, pregnancy, disease phenotype and drug therapy. Classical genetic alterations are not generally found more often in IBD patients than in non-IBD patients, suggesting that genetics does not explain the greater risk of VTE in these patients. IBD VTE may have clinical specificities, namely an earlier first episode of VTE in life, high recurrence rate, decreased efficacy of some drugs in preventing further episodes and poor prognosis.