Research Report
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World J Gastroenterol. Apr 21, 2014; 20(15): 4393-4400
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4393
Living-donor or deceased-donor liver transplantation for hepatic carcinoma: A case-matched comparison
Ping Wan, Jian-Jun Zhang, Qi-Gen Li, Ning Xu, Ming Zhang, Xiao-Song Chen, Long-Zhi Han, Qiang Xia
Ping Wan, Jian-Jun Zhang, Qi-Gen Li, Ning Xu, Ming Zhang, Xiao-Song Chen, Long-Zhi Han, Qiang Xia, Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Author contributions: Xia Q is the guarantor and designed the study; Wan P conducted the majority of the study and wrote the manuscript; Xia Q, Zhang JJ, Li QG, Xu N, Zhang M, Chen XS and Han LZ offered suggestions for this work and revised the manuscript.
Supported by Key Discipline and Specialty Foundation of Shanghai Municipal Commission of Health and Family Planning; Training Program for Superb Academic Leaders in Shanghai Health System, No. XBR2011029; Special Fund for Building of Leading Talent Teams in Shanghai
Correspondence to: Qiang Xia, Professor, Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai 200127, China. xiaqiang@medmail.com.cn
Telephone: +86-21-68383775 Fax: +86-21-58737232
Received: September 29, 2013
Revised: December 30, 2013
Accepted: February 17, 2014
Published online: April 21, 2014
Core Tip

Core tip: Several retrospective studies from single centers have shown that living-donor liver transplantation (LDLT) might be associated with higher rates of tumor recurrence than deceased-donor liver transplantation (DDLT). In this study, we compared the surgical outcomes between LDLT and DDLT in patients with hepatic carcinoma using a multivariate case-matched method, which minimized the disparity from case selection and thus made our results statistically more persuasive than others. Our results suggest that LDLT did not show any inferiority in long-term overall survival or relapse-free survival in comparison with DDLT.