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World J Gastroenterol. Apr 14, 2014; 20(14): 4017-4024
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4017
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4017
Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors
Valentin Becker, Stefan Grotz, Christoph Schlag, Simon Nennstiel, Analena Beitz, Roland M Schmid, Alexander Meining, Monther Bajbouj, II. Medizinische Klinik und Poliklinik, Technische Universität München, D-81675 Munich, Germany
Bernhard Haller, Institut für Medizinische Statistik und Epidemiologie, Technische Universität München, D-81675 Munich, Germany
Author contributions: Becker V, Schmid RM, Meining A and Bajbouj M contributed to study design; Becker V, Schlag C and Nennstiel S contributed to pH-metry, Impedance Monitoring; Grotz S, Beitz A and Haller B contributed to data collection and statistics.
Correspondence to: Valentin Becker, MD, II. Medizinische Klinik, Technische Universität München, Klinikum Rechts der Isar, Ismaningerstr. 22, D-81675 Munich, Germany. valentin.becker@lrz.tum.de
Telephone: +49-89-41405847 Fax: +49-89-41404816
Received: October 7, 2013
Revised: December 20, 2013
Accepted: January 8, 2014
Published online: April 14, 2014
Revised: December 20, 2013
Accepted: January 8, 2014
Published online: April 14, 2014
Core Tip
Core tip: The response rates to proton pump inhibitors in reflux disease vary. Empirical proton pump inhibitor therapy poses a substantial economic burden. Positive predictors of the therapeutic response are necessary. This study provides the highest number of reflux patients. Anamnestic, objective and subjective parameters predicting the therapeutic response were evaluated.