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World J Gastroenterol. Apr 14, 2014; 20(14): 3847-3857
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3847
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3847
Current and future molecular diagnostics in colorectal cancer and colorectal adenoma
Andy Hin-Fung Tsang, Ka-Ho Cheng, Apple Siu-Ping Wong, Nancy Bo-Yin Tsui, Lawrence Wing-Chi Chan, Benjamin Yat-Ming Yung, Sze-Chuen Cesar Wong, Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong, China
Simon Siu-Man Ng, Department of Surgery, Prince of Wales Hospital, Hong Kong, China
Brigette Buig-Yue Ma, Charles Ming-Lok Chan, Sze-Chuen Cesar Wong, State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
Author contributions: Tsang AHF, Cheng KH and Wong ASP contributed equally to this work; Tsang AHF, Cheng KH, Wong ASP and Wong SCC wrote the paper; Ng SSM, Ma BBY, Chan CML, Tsui NBY, Chan LWC, Yung BYM and Wong SCC reviewed and gave evaluable comments to the paper.
Correspondence to: Sze-Chuen Cesar Wong, Associate Professor, Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, No. 11 Yucai Road, Kowloon, Hong Kong, China. cesar.wong@polyu.edu.hk
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Received: October 11, 2013
Revised: January 10, 2014
Accepted: February 26, 2014
Published online: April 14, 2014
Revised: January 10, 2014
Accepted: February 26, 2014
Published online: April 14, 2014
Core Tip
Core tip: In this review, the molecular basis of colorectal cancer (CRC) development, the characteristics and applications of different non-invasive molecular biomarkers, as well as the technologies available for the detection were discussed. This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state, colorectal adenoma.