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World J Gastroenterol. Apr 7, 2014; 20(13): 3572-3581
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3572
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3572
Remote ischemic preconditioning as treatment for non-ischemic gastrointestinal disorders: Beyond ischemia-reperfusion injury
Carlos Rodrigo Camara-Lemarroy, Departamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, México
Correspondence to: Carlos Rodrigo Camara-Lemarroy, MD, Departamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, Monterrey, NL 64460, México. crcamara83@hotmail.com
Telephone: +52-81-83337798 Fax: +52-81-83337798
Received: July 19, 2013
Revised: October 23, 2013
Accepted: January 2, 2014
Published online: April 7, 2014
Processing time: 259 Days and 14.8 Hours
Revised: October 23, 2013
Accepted: January 2, 2014
Published online: April 7, 2014
Processing time: 259 Days and 14.8 Hours
Core Tip
Core tip: Ischemia-reperfusioin injury, which commonly occurs during transplant procedures, is associated with inflammatory cytokine release, endothelial dysfunction and oxidative stress. Remote ischemic-preconditioning is a procedure that can attenuate all of these alterations. The pathophysiology of many non-ischemic gastrointestinal disorders, such as radiation-induced enteritis and inflammatory bowel disease, among others, involves many of these same mechanisms. Future research should address the question of whether remote ischemic-preconditioning could also favorably alter the course of these diseases.