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World J Gastroenterol. Apr 7, 2014; 20(13): 3443-3456
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3443
Immunologic, metabolic and genetic factors in hepatitis C virus infection
Nora A Fierro, Karina Gonzalez-Aldaco, Rafael Torres-Valadez, Erika Martinez-Lopez, Sonia Roman, Arturo Panduro
Nora A Fierro, Karina Gonzalez-Aldaco, Rafael Torres-Valadez, Erika Martinez-Lopez, Sonia Roman, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde” and Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, Mexico
Author contributions: Fierro NA analyzed data, wrote the paper and critically revised the manuscript; Gonzalez-Aldaco K, Torres-Valadez R and Martinez-Lopez E performed the research; Roman S analyzed the data; Panduro A conceived, drafted, analyzed data and critically revised the manuscript; all authors revised and approved the final version.
Supported by The National Council of Science and Technology (CONACYT-FONDO SECTORIAL, Mexico), Grant No. Salud-2010-1-139085 to Roman S; CONACYT-CIENCIA BASICA, Mexico, Grant No. 127229, COECYTJAL-UDG, Mexico, Grants No. S-2010-1-849, CONACYT-INFR, Mexico and Grant No. 188240 to Fierro NA
Correspondence to: Arturo Panduro, MD, PhD, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde” and Health Sciences Center, University of Guadalajara, 278, Col El Retiro, Guadalajara 44280, Jalisco, Mexico. apanduro@prodigy.net.mx
Telephone: +52-33-36147743 Fax: +52-33-36147743
Received: September 27, 2013
Revised: January 16, 2014
Accepted: March 6, 2014
Published online: April 7, 2014
Core Tip

Core tip: Immunologic, metabolic and genetic factors are involved in the progression of hepatitis C virus (HCV) infection and the response to treatment. The significant increase in obesity worldwide, including in Mexico, imposes a new metabolic stress factor in patients with HCV infection. Given that the lipid components associated with HCV infection are finely modulated, it is possible that the progression of HCV infection may be regulated by the characteristics of the population’s lipid composition.