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World J Gastroenterol. Mar 28, 2014; 20(12): 3245-3254
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3245
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3245
Inflammatory bowel disease of primary sclerosing cholangitis: A distinct entity?
Takahiro Nakazawa, Itaru Naitoh, Kazuki Hayashi, Katsuyuki Miyabe, Shuya Shimizu, Takashi Joh, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
Hitoshi Sano, Department of Gastroenterology, Gifu Prefectual Tajimi Hospital, Gifu 507-0042, Japan
Author contributions: Nakazawa T, Naitoh I and Sano H designed the research; Hayashi K, Miyabe K and Shimizu S collected clinical data; Nakazawa T and Joh T analyzed data; Nakazawa T and Naitoh I wrote the paper.
Correspondence to: Takahiro Nakazawa, MD, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. tnakazaw@med.nagoya-cu.ac.jp
Telephone: +81-52-8538211 Fax: +81-52-8520952
Received: August 28, 2013
Revised: January 8, 2014
Accepted: January 19, 2014
Published online: March 28, 2014
Processing time: 211 Days and 1.6 Hours
Revised: January 8, 2014
Accepted: January 19, 2014
Published online: March 28, 2014
Processing time: 211 Days and 1.6 Hours
Core Tip
Core tip: Inflammatory bowel disease (IBD)-associated with primary sclerosing cholangitis (PSC) (PSC-IBD) shows an increased incidence of pancolitis, mild symptoms, and colorectal malignancy. Although an increased incidence of pancolitis is a characteristic finding, some cases are endoscopically diagnosed as right-sided ulcerative colitis. Pathological studies have revealed that inflammation occurs more frequently in the right colon than the left colon. The cholangiographic findings of immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) are similar to those of PSC. The rare association between IBD and IgG4-SC and the unique characteristics of PSC-IBD are useful findings for distinguishing PSC from IgG4-SC.