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World J Gastroenterol. Mar 28, 2014; 20(12): 3208-3222
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3208
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3208
Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Szentagothai Research Centre, 7624 Pecs, Hungary
Patricia Sarlos, 1st Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary
Andras Javorhazy, Department of Urology, University of Pecs, Munkacsy 2, 7621 Pecs, Hungary
Author contributions: Magyari L, Kovesdi E, Sarlos P, Javorhazy A, Sumegi K and Melegh B contributed equally to this work; Melegh B conceived the study; Magyari L and Kovesdi E wrote the genetic part; Sarlos P and Sumegi K wrote the clinical section; Javorhazy A prepared the figures and the table.
Supported by The grant of the Hungarian Science Foundation, No. OTKA K103983
Correspondence to: Bela Melegh, MD, PhD, DSc, Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary. bela.melegh@aok.pte.hu
Telephone: +36-72-536427 Fax: +36-72-536032
Received: September 27, 2013
Revised: December 20, 2013
Accepted: February 20, 2014
Published online: March 28, 2014
Processing time: 180 Days and 16.2 Hours
Revised: December 20, 2013
Accepted: February 20, 2014
Published online: March 28, 2014
Processing time: 180 Days and 16.2 Hours
Core Tip
Core tip: Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) are chronic, progressive disorders of the gastrointestinal tract. Different genes, including interleukin genes play central role in mediating and modulating of inflammation in inflammatory bowel diseases. In this review we summarized the interleukin and the interleukin receptor genes associated with Crohn’s disease and/or ulcerative colitis performing an electronic search on the PubMed database focusing on the following terminology: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, interleukin and interleukin receptor.