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World J Gastroenterol. Mar 21, 2014; 20(11): 3011-3017
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.3011
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.3011
Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
Sang Hwa Lee, Hyun-Soo Kim, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, Chungcheongbuk-do 363-849, South Korea
Sung-Im Do, Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, South Korea
Author contributions: Lee SH and Do SI contributed equally to this work in the design of the study, acquisition of the data and interpretation of the results; Do SI provided vital reagents and analytical tools; Lee SH drafted the manuscript; Kim HS and Do SI revised the manuscript critically and provided vital guidance to the study; all authors approved the final version of the manuscript.
Supported by Aerospace Medicine Research Project funded by the Medical Division, Headquarter, Republic of Korea Air Force (2012)
Correspondence to: Hyun-Soo Kim, MD, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do 363-849, South Korea. apkimhs@gmail.com
Telephone: +82-43-2905461 Fax: +82-43-2948951
Received: July 1, 2013
Revised: November 20, 2013
Accepted: January 6, 2014
Published online: March 21, 2014
Processing time: 259 Days and 16.9 Hours
Revised: November 20, 2013
Accepted: January 6, 2014
Published online: March 21, 2014
Processing time: 259 Days and 16.9 Hours
Core Tip
Core tip: We observed that both hypoxic and hyperoxic rat livers exhibited significantly higher frequencies of hepatic cirrhosis than untreated rat livers. We also observed that hepatic transforming growth factor-β (TGF-β) expression in hyperoxic rats was significant higher than that in untreated rats, suggesting that TGF-β is involved in the acceleration of hepatic fibrosis under hyperoxic conditions. To the best of our knowledge, up-regulated TGF-β expression in the livers of cirrhotic rats exposed to hyperoxia has not been reported.