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World J Gastroenterol. Mar 21, 2014; 20(11): 2913-2926
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.2913
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.2913
Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases
Megha Haridas Upadya, Jude Juventus Aweya, Yee-Joo Tan, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore 117597, Singapore
Yee-Joo Tan, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore
Author contributions: Tan YJ designed the research; Upadya MH performed the research; Upadya MH, Aweya JJ and Tan YJ co-wrote the manuscript; all authors read and approved the final version of the manuscript.
Supported by Grants from the Ministry of Education of Singapore, Academic Research Fund Tier 1 Grant R-182-000-170-112
Correspondence to: Yee-Joo Tan, Associate Professor, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore. yee_joo_tan@nuhs.edu.sg
Telephone: +65-651-63692 Fax: +65-677-66872
Received: September 27, 2013
Revised: December 6, 2013
Accepted: January 19, 2014
Published online: March 21, 2014
Processing time: 171 Days and 17.7 Hours
Revised: December 6, 2013
Accepted: January 19, 2014
Published online: March 21, 2014
Processing time: 171 Days and 17.7 Hours
Core Tip
Core tip: Alternative treatments to combat chronic hepatitis C include direct-acting antivirals targeting hepatitis C virus (HCV) enzymes and host targeting agents that interfere with host factors essential for the viral life cycle. Several members of a family of host proteins known as DEAD-box RNA helicases have been shown to modulate HCV replication. This review highlights their interaction with HCV and their role in viral replication. Since hepatocellular carcinoma (HCC) is a major cause of death among patients with chronic hepatitis C, the involvement of these DEAD-box RNA helicases in the development of HCC will also be discussed.