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World J Gastroenterol. Jan 7, 2014; 20(1): 290-295
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.290
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.290
Risk factors of lymphatic metastasis complement poor radiological detection in gallbladder cancer
Tu-Nan Yu, Bo Shen, Ning Meng, Hong Yu, Xiu-Jun Cai, The Second Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: Cai XJ and Yu TN designed the research; Yu TN, Shen B and Meng N analyzed the data; Yu TN, Shen B, Meng N and Yu H discussed and wrote the paper; and Cai XJ reviewed and modified the final version of the paper
Correspondence to: Xiu-Jun Cai, MD, ELSA, FACS, The Second Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zheda Rd 38, Hangzhou 310016, Zhejiang Province, China. cxjzu@hotmail.com
Telephone: +86-571-86006605 Fax: +86-571-86006605
Received: September 26, 2013
Revised: October 29, 2013
Accepted: November 12, 2013
Published online: January 7, 2014
Processing time: 115 Days and 22.8 Hours
Revised: October 29, 2013
Accepted: November 12, 2013
Published online: January 7, 2014
Processing time: 115 Days and 22.8 Hours
Core Tip
Core tip: High-quality lymphadenectomy is an essential part of radical resection of gallbladder cancer. However, until now, no frequently used radiological modalities could satisfy the need of precise preoperative evaluation of lymphatic status, including ultrasonography, computed tomography (CT), magnetic resonance and positron emission tomography, and most patients with lymphatic metastasis (LM) could not be detected until postoperative pathology. This study discovered two risk factors of LM as age < 60 years and carbohydrate antigen 19-9 elevation. By combining these two factors to direct radiological detection of LM on CT, the total percentage of LM detected preoperatively could have a drastic increase from 31.3% to 81.8%.