Brief Article
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World J Gastroenterol. Jan 7, 2014; 20(1): 235-241
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.235
Epirubicin, Cisplatin, 5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma
Ji Eun Lee, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Young Kyoung You, Myung Ah Lee
Ji Eun Lee, Myung Ah Lee, Division of Medical Oncology, Hepato-Biliary-Pancreatic Cancer Center, Cancer Research Institute Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Division of Hepatology, Hepato-Biliary-Pancreatic Cancer Center, Cancer Research Institute Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Ji Eun Lee, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Myung Ah Lee, Department of Internal Medicine, Hepato-Biliary-Pancreatic Cancer Center, Cancer Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Young Kyoung You, Department of Surgery, Hepato-Biliary-Pancreatic Cancer Center, Cancer Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Author contributions: Lee JE and Lee MA designed, analyzed and wrote this manuscript; Bae SH, Choi JY, Yoon SK and You YK enrolled the patients, collected data and reviewed the manuscript; all authors approved the final revised the manuscript.
Correspondence to: Myung Ah Lee, MD, PhD, Department of Internal Medicine, Hepato-Biliary-Pancreatic Cancer Center, Cancer Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-040, South Korea. angelamd@catholic.ac.kr
Telephone: +82-2-22586044 Fax: +82-2-5993589
Received: June 28, 2013
Revised: October 9, 2013
Accepted: October 19, 2013
Published online: January 7, 2014
Processing time: 205 Days and 23.2 Hours
Core Tip

Core tip: For advanced and metastatic hepatocellular carcinoma (HCC), sorafenib has been used as the standard systemic treatment. However, after failure to treat with sorafenib, no effective therapy is available. In the present study, we suggested that cytotoxic combination chemotherapy might be the another option for the treatment of progressive HCC. The patients with the age over 60 and a stable primary liver mass were benefit from the chemotherapy, leading to survival prolongation. Most clinical trials are currently focused on target agent because HCC is considered to be chemo-resistant cancer. Based on our data, new clinical trials using chemotherapy should be tried beyond sorafenib.