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World J Gastroenterol. Feb 14, 2013; 19(6): 909-916
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.909
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.909
Novel CDH1 germline mutations identified in Chinese gastric cancer patients
Qin-Hua Chen, Wei Deng, Xiao-Wei Li, Xiu-Fang Liu, Ya-Ping Wang, Yi-Mei Fan, Department of Medical Genetics, Medical School, Nanjing University, Nanjing 210093, Jiangsu Province, China
Qin-Hua Chen, Wei Deng, Xiao-Wei Li, Xiu-Fang Liu, Ya-Ping Wang, Yi-Mei Fan, Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, Jiangsu Province, China
Jing-Mei Wang, Department of Pathology, Drum Tower Hospital Affiliated to Medical School, Nanjing University, Nanjing 210093, Jiangsu Province, China
Li-Feng Wang, Department of Oncology, Drum Tower Hospital Affiliated to Medical School, Nanjing University, Nanjing 210093, Jiangsu Province, China
Nong Xiao, Qiong He, Lujiang Hospital, Lujiang 231500, Anhui Province, China
Author contributions: Chen QH and Deng W contributed equally to this work; Fan YM conceived and designed the study, and drafted the manuscript; Deng W also helped to draft the manuscript; Chen QH and Deng W carried out mutation screening, case-control and bioinformatics analysis; Chen QH and Liu XF performed promoter luciferase activity assay; Li XW carried out RNA splicing analysis; Wang JM, Wang LF, Xiao N and He Q contributed to the collection of samples and clinical data; Wang YP reviewed and modified the paper; and all of the authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 30972535; the Natural Science Foundation of Jiangsu, China, No. BK2012724; the Fundamental Research Funds for the Central Universities of China, 1112021402
Correspondence to: Dr. Yi-Mei Fan, Associate Professor, Department of Medical Genetics, Medical School, Nanjing University, Hankou Road 22, Nanjing 210093, Jiangsu Province, China. ymfan@nju.edu.cn
Telephone: +86-25-83593374 Fax: +86-25-83686559
Received: July 9, 2012
Revised: December 4, 2012
Accepted: December 27, 2012
Published online: February 14, 2013
Processing time: 213 Days and 22.5 Hours
Revised: December 4, 2012
Accepted: December 27, 2012
Published online: February 14, 2013
Processing time: 213 Days and 22.5 Hours
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