Brief Article
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World J Gastroenterol. Dec 28, 2013; 19(48): 9392-9398
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9392
Clinical significance of white gastric crypt openings observed via magnifying endoscopy
Masashi Kawamura, Hitoshi Sekine, Shu Abe, Daisuke Shibuya, Katsuaki Kato, Takayuki Masuda
Masashi Kawamura, Hitoshi Sekine, Department of Gastroenterology, Sendai City Hospital, Miyagi 984-8501, Japan
Shu Abe, Department of Gastroenterology, JR Sendai Hospital, Miyagi 980-0022, Japan
Daisuke Shibuya, Katsuaki Kato, Cancer Detection Center, Miyagi Cancer Society, Miyagi 980-0011, Japan
Takayuki Masuda, Division of Pathology, Tohoku University School of Health Sciences, Miyagi 980-8575, Japan
Author contributions: Kawamura M and Sekine H contributed equally to this work; Kawamura M, Sekine H, Abe S, Shibuya D and Kato K designed the research; Kawamura M performed the endoscopic procedures, collected tissue samples, analyzed the data, and wrote the manuscript; Masuda T contributed to the histological analysis.
Correspondence to: Masashi Kawamura, MD, PhD, Department of Gastroenterology, Sendai City Hospital, Shimizukoji, Sendai, Miyagi 984-8501, Japan. dq8m-kwmr@asahi-net.or.jp
Telephone: +81-22-2667111 Fax: +81-22-2118972
Received: August 1, 2013
Revised: October 7, 2013
Accepted: November 3, 2013
Published online: December 28, 2013
Processing time: 166 Days and 3.9 Hours
Core Tip

Core tip: Recent studies have reported that advances in magnifying endoscopy (ME) have led to better correlations between histopathological findings and the ME features of Helicobacter pylori (H. pylori)-induced gastritis. However, the ME findings regarding H. pylori-induced severe inflammation are insufficient. Therefore, we evaluated the relationship between H. pylori-induced gastritis and the whiteness of gastric mucosal crypt openings (COs) in the gastric corpus using ME. Our results showed that mononuclear cell and neutrophil infiltration differed significantly among the CO subtypes. CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation or activity induced by H. pylori in the gastric corpus.