Fan HY, Zhang ZL, Liu K, Yang MY, Lv WH, Che X, Xu H, Song WW. Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis. World J Gastroenterol 2013; 19(48): 9318-9327 [PMID: 24409058 DOI: 10.3748/wjg.v19.i48.9318]
Corresponding Author of This Article
Wei-Wei Song, Master of Medicine, School of Pharmacy, Yantai University, No. 32 Qingquan Road, Yantai 264005, Shandong Province, China. songweiwei2011@163.com
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Original Article
Open-Access Policy of This Article
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World J Gastroenterol. Dec 28, 2013; 19(48): 9318-9327 Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9318
Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis
Hua-Ying Fan, Zi-Liang Zhang, Ke Liu, Ming-Yan Yang, Wei-Hong Lv, Xin Che, Hui Xu, Wei-Wei Song
Hua-Ying Fan, Wei-Wei Song, Ke Liu, Ming-Yan Yang, Xin Che, Hui Xu, School of Pharmacy, Yantai University, Yantai 264005, Shandong Province, China
Zi-Liang Zhang, College of Life Science, Jilin University, Changchun 130012, Jilin Province, China
Ke Liu, Ming-Yan Yang, Xin Che, Hui Xu, Shandong Target Drug Research Co. Ltd., Yantai 264005, Shandong Province, China
Wei-Hong Lv, Shandong Target Drug Research Co. Ltd., Yantai 264005, Shandong Province, China
Author contributions: Fan HY and Liu K designed the research; Zhang ZL, Yang MY, Che X, Lv WH and Song WW performed the research; Xu H analyzed the data; and Yang MY and Song WW wrote the paper.
Supported by National Program for Important New Drugs R and D, No. 2011ZX9102-006-04; Programs for Science and Technology Development and Plan of Yantai, No. 2013ZH086
Correspondence to: Wei-Wei Song, Master of Medicine, School of Pharmacy, Yantai University, No. 32 Qingquan Road, Yantai 264005, Shandong Province, China. songweiwei2011@163.com
Telephone: +86-535-6706030 Fax: +86-535-6706066
Received: August 28, 2013 Revised: October 16, 2013 Accepted: November 1, 2013 Published online: December 28, 2013 Processing time: 139 Days and 4.1 Hours
Core Tip
Core tip: Current therapies for inflammatory bowel disease are limited by lack of effectiveness, drug refractoriness or severe adverse effects. Therefore, there is an urgent need for more effective and safe therapeutic approaches. Due to their favourable effect and less side effects, looking for novel agents from herbal and natural products has been a research focus for a long time. Previous studies demonstrate that hydroxynaphthoquinones exert therapeutic action on chronic inflammatory disease. In this study, hydroxynaphthoquinones showed beneficial effect on 2,4,6-trinitrobenzene sulfonic acid-induced colitis via tumor necrosis factor-α inhibition, and the effect was comparable to that of mesalazine. This provides pharmacological evidence for its clinical application.
