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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Dec 21, 2013; 19(47): 9092-9103
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9092
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9092
Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats
Feng Chen, Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Feng Chen, Frederik De Keyzer, Yuan-Bo Feng, Marlein Miranda Cona, Jie Yu, Guy Marchal, Raymond Oyen, Yi-Cheng Ni, Theragnostic Laboratory, Department of Imaging and Pathology, University Hospital, University of Leuven, Herestraat 49, Bus 7003, 3000 Leuven, Belgium
Author contributions: All the authors substantially contributed to conception and design, acquisition of data, or analysis and interpretation of data, drafting the article or revising it critically for important intellectual content, and final approval of the version to be published; Chen F, Feng YB, Yu J and Ni YC conducted animal experiments; Chen F and Keyzer FD performed statistical analyses.
Supported by National Natural Science Foundation of China, No. 30670603
Correspondence to: Feng Chen, MD, PhD, Deputy Director, Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. chenfengbe@aliyun.com
Telephone: +86-571-87236587 Fax: +86-571-87236587
Received: July 31, 2013
Revised: October 19, 2013
Accepted: November 3, 2013
Published online: December 21, 2013
Processing time: 173 Days and 18.7 Hours
Revised: October 19, 2013
Accepted: November 3, 2013
Published online: December 21, 2013
Processing time: 173 Days and 18.7 Hours
Core Tip
Core tip: The combination therapy with ZD6126 and thalidomide significantly delayed liver tumor growth due to synergistic effects by inducing cumulative tumor necrosis in rodents. The apparent diffusion coefficient (ADC)high performed significantly better than ADCall for the monitoring of tumor necrosis on day 2. The ADCperf could better reflect the reduction of blood flow due to the vessel shutdown induced by ZD6126, compared to the ADClow. The ADCperf could provide valuable perfusion information from diffusion weighted magnetic resonance imaging data.