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World J Gastroenterol. Dec 14, 2013; 19(46): 8789-8792
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8789
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8789
Acute cholestatic hepatitis caused by amoxicillin/clavulanate
Daniel Oliveira Beraldo, Joanderson Fernandes Melo, Alexandre Vidal Bonfim, Andrei Alkmim Teixeira, Ricardo Alkmim Teixeira, Department of Internal Medicine, Hospital Renascentista, Pouso Alegre, MG 37550-000, Brazil
Daniel Oliveira Beraldo, Andrei Alkmim Teixeira, Escola Paulista de Medicina - UNIFESP, Nephrology Department, São Paulo, SP 04023-062, Brazil
Alexandre Vidal Bonfim, Escola Paulista de Medicina - UNIFESP, Cardiology Department, São Paulo, SP 04023-062, Brazil
Ricardo Alkmim Teixeira, Cardiology Department, Instituto do Coração - FMUSP, São Paulo, SP 05403-900, Brazil
André Loyola Duarte, Pathology Department, Hospital A.C. Camargo, São Paulo, SP 01509-010, Brazil
Author contributions: Beraldo DO and Melo JF contributed equally to this work; Beraldo DO and Melo JF designed and performed research, and analyzed data; Bonfim AV, Teixeira AA, Teixeira RA, Duarte AL contributed new reagents and analytic tools; and Beraldo DO wrote the paper.
Correspondence to: Daniel Oliveira Beraldo, MD, MsC, Department of Internal Medicine, Hospital Renascentista, Salvador dos Santos Nora street, n76, Pouso Alegre, MG 37550-000, Brazil. daniel_beraldo@hotmail.com
Telephone: +55-35-34235553 Fax: +55-35-34235553
Received: April 25, 2013
Revised: September 14, 2013
Accepted: September 16, 2013
Published online: December 14, 2013
Processing time: 237 Days and 7.4 Hours
Revised: September 14, 2013
Accepted: September 16, 2013
Published online: December 14, 2013
Processing time: 237 Days and 7.4 Hours
Core Tip
Core tip: This report describes a case of acute cholestatic hepatitis caused by the use of amoxicillin/clavulanate. This case presented an unusual evolution, characterized by severe hyperbilirubinemia and cholestatic symptoms without the development of hepatic failure, and with total resolution requiring no specific treatment. There are few case reports in the literature that describe a similar clinical condition due to drug-induced cholestatic hepatitis.