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World J Gastroenterol. Dec 14, 2013; 19(46): 8764-8769
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8764
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8764
Silencing Bmi-1 enhances the senescence and decreases the metastasis of human gastric cancer cells
Feng-Lan Gao, Wei-Shan Li, Chun-Ling Liu, Pathological Examination and Research Center, Luohe Medical College, Luohe 462002, Henan Province, China
Feng-Lan Gao, Guo-Qiang Zhao, Basic Medical Science Institute, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Author contributions: Gao FL and Zhao GQ designed the research; Li WH and Liu CL performed this work; Li WS analyzed the data and wrote the paper.
Supported by The Provincial Nature Science Foundation of Henan Education Department, No. 2009C310007, to Gao FL
Correspondence to: Feng-Lan Gao, Professor, Pathological Examination and Research Center, Luohe Medical College, College Road, Huiyuan District, Luohe 462002, Henan Province, China. lmcgfl@163.com
Telephone: +86-395-2964847 Fax: +86-395-2964847
Received: June 28, 2013
Revised: September 11, 2013
Accepted: September 29, 2013
Published online: December 14, 2013
Processing time: 172 Days and 11.6 Hours
Revised: September 11, 2013
Accepted: September 29, 2013
Published online: December 14, 2013
Processing time: 172 Days and 11.6 Hours
Core Tip
Core tip: The overexpression of Bmi-1 contributes to the development of cancers. This study aimed at to evaluate the impact of Bmi-1 on the senescence and metastasis of human gastric cancer. The results demonstrated that inhibition of Bmi-1 gene expression can enhance the senescence of human gastric cancer cells and inhibit the invasion and metastasis of gastric cancer. This research has provided an indication that Bmi-1 inhibitors might be developed as new agents for gastric cancer.