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World J Gastroenterol. Dec 14, 2013; 19(46): 8652-8658
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8652
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8652
Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett’s esophagus: A pilot ex-vivo study
Yutaka Tomizawa, Prasad G Iyer, Louis M Wongkeesong, Navtej S Buttar, Lori S Lutzke, Kenneth K Wang, Barrett’s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, MN 55905, United States
Tsung-Teh Wu, Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, MN 55905, United States
Author contributions: Tomizawa Y and Wang KK contributed to the Study design, data analysis, and manuscript preparation; Iyer PG, Wongkeesong LM and Buttar NS contributed to the endocytoscopy interpretation; Wang KK contributed to the endoscopic treatment and reviewer of the paper; Wu TT contributed to the histopathology assessment; Tomizawa Y and Lutzke LS contributed to the data collection.
Correspondence to: Kenneth K Wang, MD, Professor, Barrett’s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, 1st Street SW, Rochester, MN 55905, United States. wang.kenneth@mayo.edu
Telephone: +1-507-2842174 Fax: +1-507-2557612
Received: May 1, 2013
Revised: October 7, 2013
Accepted: October 13, 2013
Published online: December 14, 2013
Processing time: 231 Days and 6.6 Hours
Revised: October 7, 2013
Accepted: October 13, 2013
Published online: December 14, 2013
Processing time: 231 Days and 6.6 Hours
Core Tip
Core tip: The current gold standard for surveillance of esophageal adenocarcioma in Barretts’s esophagus (BE) is endoscopic random biopsy and pathological diagnosis. Endocytoscopy (ECS) has the potential to provide a virtual histological diagnosis in vivo and in real-time. However, a major issue relates to that interpretation of cellular and nuclear images may be subject to similar interobserver variability associated with conventional histopathological diagnosis, and there have been no reliable classification systems for the endocytoscopic diagnosis. We presented the first study to investigate classification system of ECS in BE. This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement.