Neo-adjuvant radiotherapy in rectal cancer

doi:10.3748/wjg.v19.i46.8489

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Dec 14, 2013 (publication date) through May 19, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2013; 19(46): 8489-8501
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8489

Neo-adjuvant radiotherapy in rectal cancer

Bengt Glimelius

Bengt Glimelius, Department of Radiology, Oncology and Radiation Science, Uppsala University, SE-751 85, Sweden

Author contributions: Glimelius B contributed to the manuscript.

Supported by Swedish Cancer Society

Correspondence to: Bengt Glimelius, MD, Professor of Oncology, Department of Radiology, Oncology and Radiation Science, Uppsala University, S-75105 Uppsala, SE-751 85, Sweden. bengt.glimelius@onkologi.uu.se

Telephone: +46-18-6115513 Fax: +46-18-6111027

Received: September 10, 2013
Revised: October 17, 2013
Accepted: November 1, 2013
Published online: December 14, 2013

Core Tip

Core tip: Neo-adjuvant radiotherapy is beneficial to many rectal cancer patients since it reduces the risk of a local failure. Provided surgery is optimized, it does not substantially improve overall survival. This review describes the results of the randomized trials that form the basis for the present treatment recommendations. It also pinpoints reasons for differences in the care of rectal cancer patients seen worldwide. Finally, the concept of organ preservation is critically discussed.